What is ADEPT-2?

ADEPT-2 is a multi-centre, randomised controlled trial for autistic adults comparing Guided Self-Help with NHS support for depression.

Depression is a common mental health problem that affects many people, including autistic people.

Guided Self-Help (GSH) for low mood/depression is a psychological intervention based on the principles of Cognitive Behaviour Therapy (CBT).  Guided Self-Help means that someone is provided with written materials and sessions with a therapist to ‘guide’ their use of those materials. We have developed written materials especially for autistic people and their therapist guide.

Results from our previous study showed that autistic people and therapist guides found the materials acceptable. We would now like to find out how effective these materials are and how useful people find them compared to the support that is usually available. We would also like to find out whether GSH represents good value for money for clinical services.

We would also like to invite carers of autistic adults who wish to take part to join the study. This is so we can understand the impact on carers.

How can I get involved?

There are a number of ways you can get involved with ADEPT-2.

Click on the link below that is relevant to you:


I am an autistic adult and I want to take part in the study

I want to refer an individual to the study



  I am a carer




I am part of the research team for the study 

I am an ADEPT GSH Coach           



I am a CBT therapist in an NHS service offering support for depression

I would like to contribute to the study as an expert by experience


The Central Research Team is based at the University of Bristol. For general enquires you can contact us by email: adept-rct@bristol.ac.uk or phone: 07855 973171.

If you are interested in taking part and would like to receive more information, please visit the Take Part Page, or contact us by email: awp.adept2rctsecure@nhs.net or phone: 07855 973171.


Useful links 

Information for Participants

How we use data

Participating sites

Contact Us