What is ADEPT-2?

ADEPT-2 is a multi-centre, randomised controlled trial for autistic adults comparing Guided Self-Help with NHS support for depression.

Depression is a common mental health problem that affects many people and is related to reduced quality of life.  Research suggests that autistic people are more likely to experience depression than non-autistic people.

Effective treatments for depression exist and include low-intensity cognitive behaviour therapy (CBT).  CBT is a psychological (talking) therapy. Low-intensity refers to a form of CBT which supports people to use evidence-based information. This is often called ‘guided self-help’ (GSH). Research shows that GSH can be helpful for depression for non-autistic adults, but it is not clear if it is also helpful for autistic adults.

The primary aim of the ADEPT-2 study is to  find out if GSH is helpful in reducing depression experienced by autistic adults.

We would also like to find out if GSH is a cost-effective treatment and represents good value for money for the NHS.

We would also like to find out if GSH has an impact on family carers and supporters of autistic adults.

How can I get involved?

There are a number of ways you can get involved with ADEPT-2. Click on the link below that is relevant to you:


I am an autistic adult and I want to take part in the study.

I want to refer an individual to the study



  I am a family carer




I am part of the research team for the study 

I am an ADEPT GSH Coach           



I am a CBT therapist in an NHS service offering support for depression

I would like to contribute to the study as an expert by experience


The Central Research Team is based at the University of Bristol. For general enquires you can contact us by email: adept-rct@bristol.ac.uk or phone: 07855 973171.

If you are interested in taking part and would like to receive more information, please visit the Take Part Page, or contact us by email: awp.adept2rctsecure@nhs.net or phone: 07855 973171.


Useful links 

Information for Participants

How we use data

Participating sites

Contact Us