About the study


ADEPT-2 builds on an earlier study called ADEPT which investigated if NHS psychological therapy for depression could be adapted to meet the needs of autistic people. We developed an intervention called Guided Self-Help (GSH) with feedback and help from autistic adults. Seventy autistic adults experiencing depression took part in a pilot feasibility randomised controlled trial. They were randomly allocated to GSH or NHS care for depression.  Those who received GSH said they found it acceptable.

Why ADEPT-2?

Depression is a common mental health problem that affects many people, including autistic people.

Guided Self-Help (GSH) for low mood/depression is a psychological intervention based on the principles of Cognitive Behaviour Therapy (CBT).  Guided Self-Help means that someone is provided with written materials and sessions with a therapist to ‘guide’ their use of those materials. We have developed written materials especially for autistic people and their therapist guide.

Results from our previous study showed that autistic people and therapist guides found the materials acceptable. We would now like to find out how effective these materials are and how useful people find them compared to the support that is usually available. We would also like to find out whether GSH represents good value for money for clinical services.

We would also like to invite carers of autistic adults who wish to take part to join the study. This is so we can understand the impact on carers.

We are now unable to accept any further Expressions of Interest for the ADEPT2 study. Thank you very much for your interest. 

How can I get Involved?

If you are interested in taking part, you can express your interest, or read more about what taking part in the study involves.

If you are a health or social care professional and would like to refer an individual to the study /would like more information about the study, please click here, or contact the central study team: adept-rct@bristol.ac.uk


If you are a carer of an ADEPT-2 participant and you are interested in taking part, please read more about the ADEPT-2 Carer study here, or email us to receive a carers invitation pack: awp.adept2rctsecure@nhs.net.


If you are a psychological therapies service and would like to access the therapist training resources and/or find out more about ADEPT-2, please click here, or contact us by emailing: bath_adept-2@bath.ac.uk.


The Central Research Team is based at the University of Bristol. For general enquires you can contact us by email: adept-rct@bristol.ac.uk.

If you are interested in taking part and would like to receive more information, please visit the Take Part Page, or contact us by email: awp.adept2rctsecure@nhs.net.

Useful links 

Information for Participants

Participant Information Leaflet

Carer Study

Carer Information Leaflet

Information for Clinicians

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